APBA2 (D8A6) Rabbit mAb

• 产品编号：CST-12731S      品牌：CST       原厂货号：12731S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

APBA2 (D8A6) Rabbit mAb 能够检测内源性的APBA2总蛋白。该单克隆抗体是由合成的人源APBA2蛋白缬氨酸(123位)肽段免疫动物而制备的。β淀粉样A4 蛋白前体结合家族A成员2 (APBA2) 是一种神经元衔接蛋白，与β淀粉样前体蛋白 (APP)相互作用 (1)。β淀粉样蛋白（Aβ）是淀粉样蛋白斑的主要组成部分，阿尔茨海默氏病的病理标志（2）。已证实APBA2能够稳定APP代谢以及抑制Aβ的分泌（3）。APBA2通过转接蛋白的胞质域介导APP和神经的I型膜蛋白Alcadein（Alc）之间的相互作用，从而在神经元中形成一个三种蛋白构成的三聚体（4）。

1. Sakuma, M. et al. (2009) J Neurochem 109, 465-75.
2. Saito, Y. et al. (2008) J Biol Chem 283, 35763-71.
3. Araki, Y. et al. (2003) J Biol Chem 278, 49448-58.
4. Sano, Y. et al. (2006) J Biol Chem 281, 37853-60.

原厂资料：

Specificity / Sensitivity

APBA2 (D8A6) Rabbit mAb recognizes endogenous levels of total APBA2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val23 of human APBA2 protein.

Background

Amyloid β A4 precursor protein-binding family A member 2 (APBA2) is a neuronal adaptor protein that interacts with the amyloid β precursor protein (APP) (1). The amyloid β-protein (Aβ) is the principal component of amyloid plaques, a pathological hallmark of Alzheimer’s disease (2). APBA2 has been shown to stabilize APP metabolism and suppress the secretion of Aβ (3). APBA2 mediates interaction between APP and the neural type I membrane protein Alcadein (Alc) by linking their cytoplasmic domains, thereby forming a tripartite complex of the three proteins in neurons (4).

1. Sakuma, M. et al. (2009) J Neurochem 109, 465-75.
2. Saito, Y. et al. (2008) J Biol Chem 283, 35763-71.
3. Araki, Y. et al. (2003) J Biol Chem 278, 49448-58.
4. Sano, Y. et al. (2006) J Biol Chem 281, 37853-60.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.