PANK2 (D11E2) Rabbit mAb (Mouse Specific)

• 产品编号：CST-12479S      品牌：CST       原厂货号：12479S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

PANK2 (D11E2) Rabbit mAb 兔单抗(Mouse Specific)可以识别内源性PANK2总蛋白水平。合成对应小鼠PANK2蛋白的Leu76及其邻近氨基酸序列的肽段免疫动物获得单克隆抗体。泛酸激酶2（PANK2）在辅酶A合成的第一步中起催化反应（1,2）。人PANK2位于线粒体内，该基因的某些突变跟神经退行有关（2）。不同的是，小鼠的PANK2定位于胞浆中，该蛋白的缺陷会导致小鼠视网膜退化（1,3）。

1. Leonardi, R. et al. (2007) FEBS Lett 581, 4639-44.
2. Zhang, Y.M. et al. (2006) J Biol Chem 281, 107-14.
3. Kuo, Y.M. et al. (2005) Hum Mol Genet 14, 49-57.

原厂资料：

Specificity / Sensitivity

PANK2 (D11E2) Rabbit mAb (Mouse Specific) recognizes endogenous levels of total PANK2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu76 of mouse PANK2 protein.

Background

PANK2, pantothenate kinase 2, catalyzes the first step in CoA biosynthesis (1,2). Human PANK2 is located in the mitochondria, and research studies have shown some mutations in human PANK2 are linked to neurodegeneration (2). Alternatively, mouse PANK2 localizes in the cytosol, and defective PANK2 in mice leads to retinal degeneration (1,3).

1. Leonardi, R. et al. (2007) FEBS Lett 581, 4639-44.
2. Zhang, Y.M. et al. (2006) J Biol Chem 281, 107-14.
3. Kuo, Y.M. et al. (2005) Hum Mol Genet 14, 49-57.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody