COX IV (4D11-B3-E8) Mouse mAb

产品编号：CST-11967S 品牌：CST 原厂货号：11967S
产品分类：抗体 > 一抗 > 蛋白特异性一抗
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包装：

运保温度:

–20°C

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描述：

Cox IV (4D11-B3-E8) Mouse mAb 识别内源性COX IV总蛋白水平。该单克隆抗体由合成人源COX IV蛋白近C末端肽段免疫动物而制备的。细胞色素c氧化酶（COX）是一个异寡聚酶，由13个亚基组成，定位于线粒体内膜（1-3）。它是呼吸链末端的酶复合体，催化的分子氧还原为水，耦合跨线粒体内膜的质子转移，驱动ATP合成。3个大亚基形成催化核心，由线粒体DNA编码，而其他小的亚基，包括COX IV，由核基因编码。研究表明，COX活性缺陷与一些人类疾病相关（4）。COX IV抗体可以作为细胞研究试验中的有效的线粒体内参

原厂资料：

Specificity / Sensitivity

Cox IV (4D11-B3-E8) Mouse mAb recognizes endogenous levels of total Cox IV protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Cox IV protein.

Background

Cytochrome c oxidase (COX) is a hetero-oligomeric enzyme consisting of 13 subunits localized to the inner mitochondrial membrane (1-3). It is the terminal enzyme complex in the respiratory chain, catalyzing the reduction of molecular oxygen to water coupled to the translocation of protons across the mitochondrial inner membrane to drive ATP synthesis. The 3 largest subunits forming the catalytic core are encoded by mitochondrial DNA, while the other smaller subunits, including COX IV, are nuclear-encoded. Research studies have shown that deficiency in COX activity correlates with a number of human diseases (4). The COX IV antibody can be used effectively as a mitochondrial loading control in cell-based research assays.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.