HU IL-33 COATED ELISA

• 产品编号：BMS2048TEN      品牌：invitrogen       原厂货号：BMS2048TEN
• 产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
• 应用分类：

描述：

Description: The human IL-33 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human IL-33. The human IL-33 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

IL-33 is a member of the IL-1 family of cytokines, which includes IL-1alpha, IL-1 beta, IL-18 and IL-1Ra. In humans, IL-33 mRNA is predominantly found in dermal fibroblasts, bronchial and small airway epithelial cells and smooth muscle cells of skin and lung tissues. This cytokine is localized primarily in the nucleus where it is thought to play a role in transcriptional repression but can also be released from the cell. Upon wounding or infection, IL-33 is released from the cell via an atypical secretory pathway. During apoptosis, IL-33 is cleaved by caspases-3 and 7 (and most likely not caspase-1) to produce an 18-kDa fragment which is released. This cleaved form of IL-33 can bind the ST2 receptor, without subsequent signaling events. Necrosis-mediated release of IL-33 enables binding to ST2, a member of the IL-1 receptor family found on mast and Th2 effector cells, leading to the release of Th2 cytokines. The cytokine production due to IL-33 in turn activates human basophils. IL-33 influence on activation, degranulation, enhanced adhesion and survival of eosinophils has been shown. IL-33 also increases synthesis of IL-6, IL-13, IL-1beta, TNF-alpha, prostaglandin D2 and MCP-1 by primary bone marrow-derived mast cells. Other cells activated by IL-33 are cardiomyocytes, glial cells and CD34+ cells.

原厂资料：