PIN (protein inhibitor of nNOS) is a small protein of 89 amino acids initially described as a light chain subunit of dynein and as an inhibitor of
the neuronal nitric oxide synthase isoform (nNOS). In vitro, PIN has been reported to bind to a unique nNOS domain encompassing amino
acids 163-245. PIN inhibits nNOS activity and blocks the formation of the active nNOS dimer. Although ubiquitously expressed, PIN levels
are reportedly highest in brain and testis. Immunolocalization studies in Drosophila melanogaster detected a cytoplasmic distribution of PIN.
Partial-loss-of-function of PIN resulted in morphologic and developmental changes in the bristles, wings, and female sterility of D.
melanogaster. Deletion of PIN resulted in lethality with the characteristic morphology of apoptotic cells.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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