Hu CD195 PerCP-Cy5.5 3A9 50Tst

• 产品编号：BD-560635      品牌：BD-Pharmingen       原厂货号：560635
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

Reacts with the chemokine receptor, CCR5, a seven transmembrane-spanning G protein-associated molecule. 3A9 antibody has also been
reported to cross-react with human CCR8. Results of epitope mapping and sequence comparison between CCR5 and CCR8 reveals that the
first three amino acid residues for these two receptors are identical: MDY (Met-Asp-Tyr). CCR5 belongs to the β-chemokine receptor family.
It is expressed on a subset of T lymphocytes (CD3+, CD45RO+, CD95+). CCR5 regulates lymphocyte chemotaxis activation and
transendothelial migration during inflammation. It signals a response to at least three chemokines: RANTES and macrophage inflammatory
protein-1 (MIP-1) α and β. Additionally, CCR5 has been found to be a co-receptor for macrophage-tropic HIV-1 on CD4+ cells, a
characteristic that is important in viral transmission. Reports indicate that individuals who have partial (heterozygous) or complete
(homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection. CCR5 has been clustered as CD195 in the VIIth HLDA
workshop.
3A9 has been predicted to be reactive on non-human primate samples (e.g Rhesus, Cynomolgus). Investigators are advised that the
PerCP-Cy™5.5 Mouse Anti-Human CD195 (clone 3A9) antibody is not routinely tested on non-human primate samples.

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.