ERK2 Alexa 488 G263-7 50Tst

产品编号：BD-558525 品牌：BD-Pharmingen 原厂货号：558525
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The members of the Mitogen-Activated Protein Kinase (MAPK) family are components of a key signal transduction cascade that links events
at the cell surface to responses in the nucleus. The signaling cascade is found in species as varied as yeast and humans, with many of the
proteins being well conserved. In mammals the most widely studied members of the cascade are the Extracellular signal-Regulated Kinases,
ERK1 (p44 MAPK) and ERK2 (p42 MAPK). ERK1 and ERK2 share 85% homology and are activated by extracellular signals such as growth
factors, hormones, and phorbol esters. Activation occurs through a series of phosphorylations by kinases activating other kinases and
eventually leading to phosphorylation of the ERKs. Growth factor stimulation leads to activation of Ras and Raf, leading to phosphorylation
of MEK1 (MAPK/ERK kinase) which, in turn, activates the ERKs via dual phosphorylation. Once activated, the ERKs phosphorylate other
cytoplasmic signaling molecules (protein kinases and phosphatases), cell-surface receptors, microtubule-associated proteins, and transcription
factors in the nucleus. Thus, the active ERK has myriad downstream effectors that implicate it in the control of cell proliferation and
differentiation, as well as regulation of the cytoskeleton. Furthermore, studies have shown that elevated ERK activity is associated with some
cancers. The G263-7 recognizes ERK2. It does not cross-react with ERK1. Clone G263-7 was originally characterized in human (A431) and
mouse (NIH/3T3) cells. A human ERK2 synthetic peptide was used as immunogen.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.