Description: The HIS41 monoclonal antibody reacts with all isoforms of the rat CD45 molecule, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in signaling and activation of lymphocytes. HIS41 reacts with strains expressing the RT7.2 alloantigen (BUF, LOU, and WF), but not strains expressing the RT7.1 alloantigen (ACI, AO, BN, DA, DZB, LEW, MAXX, PVG, SHR, and WAG).