两性霉素BAmphotericin B

产品编号：0219504380 品牌：MP 原厂货号：0219504380
产品分类：MP lifescience > Uassigned
应用分类：细胞培养产品与服务 > 哺乳动物细胞培养 > 细胞培养用抗生素 > AMPHOTERICIN 两性霉素B

包装：

100 mg

运保温度:

2-8°C

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描述：

Fungizone; Amphozone; Fungilin; Ampho-Moronal

An Antifungal agent produced by Streptomyces species.
Ref.: (1) R.C. Pandey, K.L. Rinehart, J. Antibiot., 29: 1035, (1976); (2) Mechlinski, et al., Tetrahedron Letters, 3873, (1970).

Structure:

Molecular Formula: C₄₇H₇₃NO₁₇

Molecular Weight: 924.11

CAS # : 1397-89-3

Synonyms: Fungizone; Amphozone; Fungilin; Ampho-Moronal

Source: Streptomyces species.

Physical Description: Yellow to orange powder. Depending on pH, amphotericin in solution is yellow to dark yellow.

Description: An antifungal agent. This product contains no animal-derived components.

Pk_a values: 5.5 and 10.0.³

Solubility: Soluble in acidic water (pH 2) or basic water (pH 11) (about 0.1 mg/ml). Water solubility can be increased with the addition of deoxycholic acid, sodium salt (increasing solubility with increasing concentration of deoxycholic acid). Soluble in Dimethylformamide (DMF) (2 to 4 mg/ml), DMF + 1 M HCl (3:1) (60 to 80 mg/ml), DMSO (30 to 40 mg/ml), propylene glycol; slightly soluble in methanol and methyl alcohol; insoluble in water, anhydrous alcohol, ether, benzene, and toluene. Solutions are stable for long periods between pH 4 and 10.¹

Cat# 16723 is a concentrated solution of amphotericin at neutral to slightly basic pH, which is slightly cloudy due to the low solubility of amphotericin in aqueous buffer. The concentrated solution is stable at 2-8^oC for up to 3 weeks. When diluted to the working concentration (see below for recommended concentration), the amphotericin will completely go into solution. Diluted amphotericin is stable for up to 7 days in culture at 37^oC. Store diluted solutions aliquoted at -20°C or below for up to approximately 6 months.

Sterilization of solutions should be by filtration through teflon membrane filters; Amphotericin B should not be gamma irradiated or autoclaved.

Formulation (for 16723):

*Component*	*mg/liter*	*Mol. Wt.*	*Mol. (mM)*
Amphotericin B	0.25	924.1	0.00027
Sodium Deoxycholate	250	414.6	0.60

Description: An antimicrobial/antifungal agent effect against yeast and other fungi at a recommended concentration of 2.5 ug/L (prepared solution use 10 ml/L). It is a mixture of polyenes. It interrupts cell membrane permeability by binding sterols resulting in the loss of low molecular weight compounds from the cell. Amphotericin B may be toxic to some insect cell types. It is inactive against bacteria, rickettsia and viruses. It is typically stable in media at 37°C in the dark for approximately 3 days.²¹

Availability:

Catalog Number	Description	Size
195043	Amphotericin B, powder	100 mg 250 mg 500 mg 1 g 5 g
1672346 1672348	Amphotericin B Solution, 250 ug/ml; formulated with deoxycholate and prepared in water for increased solubility, pH = 7-8	20 ml 50 ml

两性霉素B、庐山霉素、异性霉素

两性霉素B(二性霉素B)，中文别名：二性霉素B、节丝霉素B、两性霉素-B、两性霉素乙、芦山霉素、庐山霉素、异性霉素，英文别名：Amfostat、Ampho-Moronal、Amphotericin、AnfotericinaB、Fongizone、Fungilin、Fungizone、Lushanmycin、Wypicil

用途：多烯类抗真菌抗生素，通过影响细胞膜通透性发挥抑制真菌生长的作用。临床上用于治疗严重的深部真菌引起的内脏或全身感染。