HUMAN PDGF-AB- PEPROTECH

• 产品编号：100-00AB-2ug      品牌：invitrogen       原厂货号：100-00AB-2UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > PDGF血小板衍生因子
• 应用分类：

描述：

PDGFs是由二硫键连接的由两个12.0-13.5 kDa多肽链形成的二聚体，这两条多肽链分别被称为PDGF-A和PDGF-B链。PDGFs有三种天然存在形式，PDGF-AA、PDGF-BB和PDGF-AB，有效的促进多种类型细胞，包括平滑肌细胞，结缔组织细胞，骨和软骨细胞，以及一些血细胞。PDGFs存储在血小板α-颗粒中，它被释放后的血小板活化。PDGFs参与许多生物过程，包括增殖、胚胎神经元发育和呼吸道上皮细胞的发育。PDGFs两个不同的信号受体已被鉴定并命名为PDGFR-α和PDGFR-β。 PDGFR-α是对于这三种形式PDGF形成均具有高亲和力的受体。而PDGFR-β仅作用于PDGF-BB和PDGF-AB。重组人PDGF-AB是由二硫键连接26.4 kDa的二聚体，包含一个α链和一个β链（共234个氨基酸）。

原厂资料：

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one α chain and one β chain (234 total amino acids).

注意事项：

仅用于研究。不适用于诊断或治疗。