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PHOSPHO-PAXILLIN (SER178) PAB 100 UL BIOSOURCE (TM)

 
包装:
运保温度: -20°C
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描述:

Details
Tested species reactivity Human
Published species reactivity Mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human paxillin that contains serine 178.
Conjugate Unconjugated
Form Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol
Contains 0.05% sodium azide
Storage Conditions -20°C
Tested Applications Dilution *
Immunohistochemistry (Paraffin) (IHC (P)) 1:20
Western Blot (WB) Assay Dependent

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

Published Applications  
Western Blot (WB) See 1 publications below

Background/Target Information

Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.

 


注意事项:

For Research Use Only. Not for use in diagnostic procedures. 
 


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