Blasticidin S Hydrochloride is a nucleoside antibiotic from Streptomyces griseochromogenes. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to Blasticidin is conferred by the expression of the "bsd" gene or "bsr" gene. Blasticidin has a fast mode of action, causing rapid cell death at low antibiotic concentrations. E. coli strains are generally sensitive to concentrations of 50 µg/ml, while mammalian cells are sensitive to concentrations as low as 2 to 10 µg/ml. Cell death occurs rapidly, and blasticidin-resistant stable mammalian cell lines can be generated in less than one week.
Blasticidin and the blasticidin resistance gene (bsd) are the subject of U.S. Patent No. 5,527,701 sold under patent license for research purposes only. Inquiries for commercial use should be directed to: Kaken Pharmaceutical Company
C17H2N8O5•HCl Formula Weight: 458.9 g/mole Format: Liquid Solution (Sterile filtered), 10mg/mL Volume: 10 x 1mL
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