Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative.
Applications
Application
This Anti-IL-2 Rα Antibody, clone 7G7/B6 is validated for use in DB, IC for the detection of IL-2 Rα.
Key Applications
Dot Blot
Immunocytochemistry
Biological Information
Immunogen
Whole cells expressing human IL-2 Receptor α
Clone
7G7/B6
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown.
FUNCTION:SwissProt: P01589 # Receptor for interleukin-2. SIZE:272 amino acids; 30819 Da SUBUNIT:Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain. SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein. DISEASE:SwissProt: P01589 # Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942]. SIMILARITY:SwissProt: P01589 ## Contains 2 Sushi (CCP/SCR) domains.
Product Usage Statements
Quality Assurance
routinely evaluated on ice cold ethanol/acetic acid [95:5] fixed phytohemagglutinin (PHA)-treated Jurkat T lymphocytes
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C
Packaging Information
Material Size
200 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
H
DB, ICC
M
Purified
Monoclonal Antibody
Description
Catalogue Number
05-170
Brand Family
Upstate
Trade Name
Upstate
Description
Anti-IL-2 Rα Antibody, clone 7G7/B6
Product Information
Format
Purified
Control
Lung tissue
Presentation
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative.
Applications
Application
This Anti-IL-2 Rα Antibody, clone 7G7/B6 is validated for use in DB, IC for the detection of IL-2 Rα.
Key Applications
Dot Blot
Immunocytochemistry
Biological Information
Immunogen
Whole cells expressing human IL-2 Receptor α
Clone
7G7/B6
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown.
FUNCTION:SwissProt: P01589 # Receptor for interleukin-2. SIZE:272 amino acids; 30819 Da SUBUNIT:Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain. SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein. DISEASE:SwissProt: P01589 # Genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942]. SIMILARITY:SwissProt: P01589 ## Contains 2 Sushi (CCP/SCR) domains.
Product Usage Statements
Quality Assurance
routinely evaluated on ice cold ethanol/acetic acid [95:5] fixed phytohemagglutinin (PHA)-treated Jurkat T lymphocytes
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C
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