fragile X mental retardation syndrome related protein 2
fragile X-mental retardation 1-like 2
fragile X mental retardation, autosomal homolog 2
Background Information
Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding. FXR2 is very similar to FMR1 (60% identity). FXR2 encodes a 74 kDa protein which, like FMR1, contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The FXR2 gene is located on human chromosome 17 at 17p13.1. In addition, FMR1 and FXR2 interact tightly with the recently described autosomal homolog FXR1. Each of these three proteins is capable of forming heterodimers with the others, and each can also form homodimers. FXR1 and FXR2 are thus likely to play important roles in the function of FMR1 and in the pathogenesis of the Fragile X Mental Retardation Syndrome.
Product Information
Format
Purified
Control
Jurkat cell lysate
Presentation
Purified mouse monoclonal IgG1κ buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application
Use Anti-FXR2 Antibody, clone A42 (Mouse Monoclonal Antibody) validated in WB, IP, ICC to detect FXR2 also known as fragile X mental retardation syndrome related protein 2.
Key Applications
Western Blotting
Immunocytochemistry
Immunoprecipitation
Application Notes
Immunoprecipitation: Siomi, M.C., et al. (1996). Mol Cell Biol. 16(7):3825-3832
Immunocytochemistry: Wan, L., et al. (2000). Mol Cel Biol. 20(22) 8536-8547
Biological Information
Immunogen
His-tagged recombinant protein corresponding to human FXR2.
Epitope
Unknown
Clone
A42
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.
SUBUNIT STURCUTRE: Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3.
SUBCELLULAR LOCATION: Cytoplasm.
SEQUENCE SIMILARITIES: Belongs to the FMR1 family.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in jurkat cell lysate.
Western Blot Analysis: 0.1 µg/ml of this antibody detected FXR2 on 10 µg of jurkat cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size
100 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
H
WB, ICC, IP
M
Purified
Monoclonal Antibody
Description
Catalogue Number
05-1513
Description
Anti-FXR2 Antibody, clone A42
Alternate Names
fragile X mental retardation syndrome related protein 2
fragile X-mental retardation 1-like 2
fragile X mental retardation, autosomal homolog 2
Background Information
Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding. FXR2 is very similar to FMR1 (60% identity). FXR2 encodes a 74 kDa protein which, like FMR1, contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The FXR2 gene is located on human chromosome 17 at 17p13.1. In addition, FMR1 and FXR2 interact tightly with the recently described autosomal homolog FXR1. Each of these three proteins is capable of forming heterodimers with the others, and each can also form homodimers. FXR1 and FXR2 are thus likely to play important roles in the function of FMR1 and in the pathogenesis of the Fragile X Mental Retardation Syndrome.
Product Information
Format
Purified
Control
Jurkat cell lysate
Presentation
Purified mouse monoclonal IgG1κ buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application
Use Anti-FXR2 Antibody, clone A42 (Mouse Monoclonal Antibody) validated in WB, IP, ICC to detect FXR2 also known as fragile X mental retardation syndrome related protein 2.
Key Applications
Western Blotting
Immunocytochemistry
Immunoprecipitation
Application Notes
Immunoprecipitation: Siomi, M.C., et al. (1996). Mol Cell Biol. 16(7):3825-3832
Immunocytochemistry: Wan, L., et al. (2000). Mol Cel Biol. 20(22) 8536-8547
Biological Information
Immunogen
His-tagged recombinant protein corresponding to human FXR2.
Epitope
Unknown
Clone
A42
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.
SUBUNIT STURCUTRE: Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3.
SUBCELLULAR LOCATION: Cytoplasm.
SEQUENCE SIMILARITIES: Belongs to the FMR1 family.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in jurkat cell lysate.
Western Blot Analysis: 0.1 µg/ml of this antibody detected FXR2 on 10 µg of jurkat cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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