Protein tyrosine phosphatase, non-receptor type 12
Tyrosine-protein phosphatase non-receptor type12
Background Information
The protein tyrosine phosphatase PTP-PEST is an cytosolic protein tyrosine phosphatase that is ubiquitously expressed in mammalian tissues. PTP-PEST associates with multiple cytoskeleton and cell adhesion molecules suggesting a regulatory role in controlling cell shape and motility.
Product Information
Format
Ascites
Control
HeLa cell lysate
Presentation
Mouse monoclonal IgG1 ascites containing no preservatives.
Applications
Application
Anti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.
SIZE: 780 amino acids; 88120 Da
SUBUNIT: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE:SwissProt: Q05209 # Defects in PTPN12 are found in some colon cancers.
SIMILARITY: SwissProt: Q05209 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by Western Blot on HeLa lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PTP-PEST on 10 μg of HeLa lysates.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size
100 µL
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
H, R, M
WB, ICC, IP
M
Ascites
Monoclonal Antibody
Description
Catalogue Number
05-1417
Replaces
MAB3739
Description
Anti-PTP-PEST Antibody, clone AG25
Alternate Names
Protein-tyrosine phosphatase G1
Protein tyrosine phosphatase, non-receptor type 12
Tyrosine-protein phosphatase non-receptor type12
Background Information
The protein tyrosine phosphatase PTP-PEST is an cytosolic protein tyrosine phosphatase that is ubiquitously expressed in mammalian tissues. PTP-PEST associates with multiple cytoskeleton and cell adhesion molecules suggesting a regulatory role in controlling cell shape and motility.
Product Information
Format
Ascites
Control
HeLa cell lysate
Presentation
Mouse monoclonal IgG1 ascites containing no preservatives.
Applications
Application
Anti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.
SIZE: 780 amino acids; 88120 Da
SUBUNIT: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE:SwissProt: Q05209 # Defects in PTPN12 are found in some colon cancers.
SIMILARITY: SwissProt: Q05209 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by Western Blot on HeLa lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PTP-PEST on 10 μg of HeLa lysates.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
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