protein tyrosine phosphatase, receptor type, c
polypeptide-associated protein
protein tyrosine phosphatase, receptor type, C-associated protein
PTPRC-associated protein
Lymphocyte phosphatase-associated phosphoprotein
CD45-associated protein
Background Information
CD45 is a receptor-tyrosine phosphatase required for antigen-induced signaling in T-cells and B-cells; its substrates are unknown. Interestingly, it associates with several Src-family tyrosine kinases, which are inhibited by tyrosine phosphorylation in their c-termini, suggesting a mechanism for signaling by CD45.
Product Information
Format
Purified
Control
Mouse colon tissue
Presentation
Purified rabbit monoclonal IgG in phosphate buffered saline containing 10 mM sodium azide.
Applications
Application
Anti-CD45 Antibody, clone IBL-5/25 is an antibody against CD45 for use in FC, IH.
Key Applications
Flow Cytometry
Immunohistochemistry
Application Notes
Flow Cytometry Analysis: A previous lot detected CD45, clone IBL-5/25 in mouse peripheral blood lymphocytes
Biological Information
Immunogen
Mouse lymph node cells.
Clone
IBL-5/25
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rat
Specificity
This antibody reacts with all isoforms of mouse CD45 which is expressed on all haematopoietic cells except erythrocytes.
FUSION PARTNER: SP2/0 myeloma cell line
Isotype
IgG
Species Reactivity
Mouse
Species Reactivity Note
Reacts with mouse. Reactivity with other species has not been determined.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
SUBUNIT STRUCTURE:Interacts with CD45/PTPRC. SUBCELLULAR LOCATION:Membrane; Single-pass membrane protein Potential. PTM:Phosphorylated on tyrosine residues.
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in mouse colon tissue.
Immunohistochemistry Analysis: 1:100 dilution of this antibody detected CD45 in mouse colon tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Store at 2-8°C for 12 months from date of receipt.
Packaging Information
Material Size
500 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
M
FC, IHC
R
Purified
Monoclonal Antibody
Description
Catalogue Number
05-1416
Replaces
CBL1326
Description
Anti-CD45 Antibody, clone IBL-5/25
Alternate Names
CD45 associated protein
protein tyrosine phosphatase, receptor type, c
polypeptide-associated protein
protein tyrosine phosphatase, receptor type, C-associated protein
PTPRC-associated protein
Lymphocyte phosphatase-associated phosphoprotein
CD45-associated protein
Background Information
CD45 is a receptor-tyrosine phosphatase required for antigen-induced signaling in T-cells and B-cells; its substrates are unknown. Interestingly, it associates with several Src-family tyrosine kinases, which are inhibited by tyrosine phosphorylation in their c-termini, suggesting a mechanism for signaling by CD45.
Product Information
Format
Purified
Control
Mouse colon tissue
Presentation
Purified rabbit monoclonal IgG in phosphate buffered saline containing 10 mM sodium azide.
Applications
Application
Anti-CD45 Antibody, clone IBL-5/25 is an antibody against CD45 for use in FC, IH.
Key Applications
Flow Cytometry
Immunohistochemistry
Application Notes
Flow Cytometry Analysis: A previous lot detected CD45, clone IBL-5/25 in mouse peripheral blood lymphocytes
Biological Information
Immunogen
Mouse lymph node cells.
Clone
IBL-5/25
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rat
Specificity
This antibody reacts with all isoforms of mouse CD45 which is expressed on all haematopoietic cells except erythrocytes.
FUSION PARTNER: SP2/0 myeloma cell line
Isotype
IgG
Species Reactivity
Mouse
Species Reactivity Note
Reacts with mouse. Reactivity with other species has not been determined.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
SUBUNIT STRUCTURE:Interacts with CD45/PTPRC. SUBCELLULAR LOCATION:Membrane; Single-pass membrane protein Potential. PTM:Phosphorylated on tyrosine residues.
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in mouse colon tissue.
Immunohistochemistry Analysis: 1:100 dilution of this antibody detected CD45 in mouse colon tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Store at 2-8°C for 12 months from date of receipt.
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