Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
Product Information
Format
Unpurified
Control
Human pancreas tissue.
Presentation
Unpurified mouse monoclonal as liquid ascites fluid containing no preservatives.
Applications
Application
Detect Insulin using this Anti-Insulin Antibody, clone CE9H9 validated for use in IH(P).
Key Applications
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
Zinc containing crystalline human insulin
Clone
CE9H9
Host
Mouse
Specificity
The antibody binds to insulin from human, cow, pig and rabbit and to pro-insulin from cow and pig.
Isotype
IgG1
Species Reactivity
Human Fish Chicken Guinea Pig Sheep Pig Rabbit Bovine
Species Reactivity Note
Proven to react with human, bovine, pig, rabbit, sheep and guinea pig.
FUNCTION:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. SUBUNIT STRUCTURE:Heterodimer of a B chain and an A chain linked by two disulfide bonds. SUBCELLULAR LOCATION:Secreted. INVOLVEMENT IN DISEASE:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]. PHARMACEUTICAL USE:Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53. SEQUENCE SIMILARITIES:Belongs to the insulin family. SEQUENCE CAUTION:The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human pancreas tissue.
IHC Analysis: A 1.25 µg/mL dilution of this antibody detected insulin in human pancreas tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
1 year at -20°C from date of receipt
Packaging Information
Material Size
100 µL
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
H, F, Ch, Gp, Sh, Po, Rb, B
IH(P)
M
Unpurified
Monoclonal Antibody
Description
Catalogue Number
05-1107
Replaces
MAB10218
Description
Anti-Insulin Antibody, clone CE9H9
Background Information
Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
Product Information
Format
Unpurified
Control
Human pancreas tissue.
Presentation
Unpurified mouse monoclonal as liquid ascites fluid containing no preservatives.
Applications
Application
Detect Insulin using this Anti-Insulin Antibody, clone CE9H9 validated for use in IH(P).
Key Applications
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
Zinc containing crystalline human insulin
Clone
CE9H9
Host
Mouse
Specificity
The antibody binds to insulin from human, cow, pig and rabbit and to pro-insulin from cow and pig.
Isotype
IgG1
Species Reactivity
Human Fish Chicken Guinea Pig Sheep Pig Rabbit Bovine
Species Reactivity Note
Proven to react with human, bovine, pig, rabbit, sheep and guinea pig.
FUNCTION:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. SUBUNIT STRUCTURE:Heterodimer of a B chain and an A chain linked by two disulfide bonds. SUBCELLULAR LOCATION:Secreted. INVOLVEMENT IN DISEASE:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]. PHARMACEUTICAL USE:Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53. SEQUENCE SIMILARITIES:Belongs to the insulin family. SEQUENCE CAUTION:The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human pancreas tissue.
IHC Analysis: A 1.25 µg/mL dilution of this antibody detected insulin in human pancreas tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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