Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2
Alternate Names
RAR-related orphan receptor C
Retinoid-related orphan receptor-gamma
RAR-related orphan receptor C, isoform a
Nuclear receptor subfamily 1 group F member 3
RZR-GAMMA
Nuclear receptor RZR-gamma
retinoid-related orphan receptor gamma
nuclear receptor ROR-gamma
retinoic acid-binding receptor gamma
RAR-related orphan receptor gamma
Background Information
Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.
Product Information
Format
Purified
Control
EL4 cell lysate
Presentation
Purified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Detect Retinoid-Related Orphan Receptor γ T using this Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2 validated for use in WB, FC & IF.
Key Applications
Western Blotting
Biological Information
Immunogen
Histidine-tagged recombinant protein corresponding to mouse Retinoid-Related Orphan Receptor γ T (RORγT).
Epitope
Unknown
Clone
RORg2
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
FUNCTION: Orphan nuclear receptor. Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus.
SUBCELLULAR LOCATION: Nucleus Probable.
TISSUE SPECIFICTY: Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes. Neither isoform is expressed in spleen or bone marrow.
SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in EL4 cell lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected Retinoid-Related Orphan Receptor γ T (RORγT) in 10 µg of EL4 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size
100 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
M
WB
AHm
Purified
Monoclonal Antibody
Description
Catalogue Number
04-959
Description
Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2
Alternate Names
RAR-related orphan receptor C
Retinoid-related orphan receptor-gamma
RAR-related orphan receptor C, isoform a
Nuclear receptor subfamily 1 group F member 3
RZR-GAMMA
Nuclear receptor RZR-gamma
retinoid-related orphan receptor gamma
nuclear receptor ROR-gamma
retinoic acid-binding receptor gamma
RAR-related orphan receptor gamma
Background Information
Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.
Product Information
Format
Purified
Control
EL4 cell lysate
Presentation
Purified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Detect Retinoid-Related Orphan Receptor γ T using this Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2 validated for use in WB, FC & IF.
Key Applications
Western Blotting
Biological Information
Immunogen
Histidine-tagged recombinant protein corresponding to mouse Retinoid-Related Orphan Receptor γ T (RORγT).
Epitope
Unknown
Clone
RORg2
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
FUNCTION: Orphan nuclear receptor. Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus.
SUBCELLULAR LOCATION: Nucleus Probable.
TISSUE SPECIFICTY: Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes. Neither isoform is expressed in spleen or bone marrow.
SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in EL4 cell lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected Retinoid-Related Orphan Receptor γ T (RORγT) in 10 µg of EL4 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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