100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Applications
Application
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect p70 S6 Kinase using this Anti-p70 S6 Kinase Antibody, rabbit validated for use in FC, IH(P), IP & WB.
Key Applications
Western Blotting
Flow Cytometry
Immunohistochemistry (Paraffin)
Immunoprecipitation
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to the N-terminal region of human p70 S6 Kinase.
Host
Rabbit
Specificity
Recognizes the N-terminal domain of both αI and αII isoforms of p70 S6 Kinase.
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
FUNCTION:SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. SIZE:525 amino acids; 59140 Da SUBUNIT:Interacts with PPP1R9A/neurabin-1 (By similarity). SUBCELLULAR LOCATION:Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity). TISSUE SPECIFICITY:Widely expressed. SIMILARITY:SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
2 years at -20°C from date of shipment
Packaging Information
Material Size
100 µL
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
R, H, M
WB, FC, IH(P), IP
Rb
Purified
Monoclonal Antibody
Description
Catalogue Number
04-391
Brand Family
Upstate
Trade Name
Upstate
Description
Anti-p70 S6 Kinase Antibody, rabbit monoclonal
Alternate Names
ribosomal protein S6 kinase
RPS6KB1
PS6K
S6K
S6K1
STK14A
p70(S6K)-alpha
p70-S6K
p70-alpha
p70 S6 kinase, alpha 1
p70 S6 kinase, alpha 2
alpha 2
Product Information
Format
Purified
Presentation
100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Applications
Application
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect p70 S6 Kinase using this Anti-p70 S6 Kinase Antibody, rabbit validated for use in FC, IH(P), IP & WB.
Key Applications
Western Blotting
Flow Cytometry
Immunohistochemistry (Paraffin)
Immunoprecipitation
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to the N-terminal region of human p70 S6 Kinase.
Host
Rabbit
Specificity
Recognizes the N-terminal domain of both αI and αII isoforms of p70 S6 Kinase.
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
FUNCTION:SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. SIZE:525 amino acids; 59140 Da SUBUNIT:Interacts with PPP1R9A/neurabin-1 (By similarity). SUBCELLULAR LOCATION:Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity). TISSUE SPECIFICITY:Widely expressed. SIMILARITY:SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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