Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal
Alternate Names
acetyl-Coenzyme A carboxylase alpha
ACACA
ACAC
ACC
ACC1
ACCA
Product Information
Format
Purified
Presentation
100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
Applications
Application
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Acetyl CoA Carboxylase 1 Antibody, Rabbit detects level of Acetyl CoA Carboxylase 1 & has been published & validated for use in WB, IH(P).
Key Applications
Immunohistochemistry (Paraffin)
Western Blotting
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to human Acetyl CoA Carboxylase 1
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
FUNCTION:SwissProt: Q13085 # Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. COFACTOR:Biotin. & Binds 2 manganese ions per subunit. SIZE:2346 amino acids; 265554 Da SUBUNIT:Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. SUBCELLULAR LOCATION:Cytoplasm. TISSUE SPECIFICITY:Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. PTM:Phosphorylation on Ser-1263 is required for interaction with BRCA1. SIMILARITY:SwissProt: Q13085 ## Contains 1 ATP-grasp domain. & Contains 1 biotin carboxylation domain. & Contains 1 biotinyl-binding domain. & Contains 1 carboxyltransferase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 2 years at -20°C from date of shipment.
Packaging Information
Material Size
100 µL
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
R, H, M
IH(P), WB
Rb
Purified
Monoclonal Antibody
Description
Catalogue Number
04-322
Brand Family
Upstate
Trade Name
Upstate
Description
Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal
Alternate Names
acetyl-Coenzyme A carboxylase alpha
ACACA
ACAC
ACC
ACC1
ACCA
Product Information
Format
Purified
Presentation
100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
Applications
Application
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Acetyl CoA Carboxylase 1 Antibody, Rabbit detects level of Acetyl CoA Carboxylase 1 & has been published & validated for use in WB, IH(P).
Key Applications
Immunohistochemistry (Paraffin)
Western Blotting
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to human Acetyl CoA Carboxylase 1
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
FUNCTION:SwissProt: Q13085 # Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. COFACTOR:Biotin. & Binds 2 manganese ions per subunit. SIZE:2346 amino acids; 265554 Da SUBUNIT:Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. SUBCELLULAR LOCATION:Cytoplasm. TISSUE SPECIFICITY:Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. PTM:Phosphorylation on Ser-1263 is required for interaction with BRCA1. SIMILARITY:SwissProt: Q13085 ## Contains 1 ATP-grasp domain. & Contains 1 biotin carboxylation domain. & Contains 1 biotinyl-binding domain. & Contains 1 carboxyltransferase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 2 years at -20°C from date of shipment.
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