OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.
Product Information
Format
Purified
Control
Mouse OX40L/L5178Y cells
Presentation
Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.
Key Applications
Immunohistochemistry
Flow Cytometry
Application Notes
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)
Biological Information
Immunogen
Mouse OX40L cDNA-transfected NRK cells
Epitope
Extracellular domain
Clone
RM134L
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rat
Specificity
This antibody recognizes the extracellular domain of OX40L.
FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
SUBUNIT STRUCTURE: Homotrimer.
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
SEQUENCE SIMILARITIES: Belongs to the tumor necrosis factor family.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in mouse OX40L/L5178Y cells.
Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size
100 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
M
IHC, FC
R
Purified
Monoclonal Antibody
Description
Catalogue Number
04-1470
Description
Anti-OX40L (CD252) Antibody, clone RM134L
Alternate Names
CD252
Tumor necrosis factor ligand superfamily member 4
OX40 ligand
OX40L
Background Information
OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.
Product Information
Format
Purified
Control
Mouse OX40L/L5178Y cells
Presentation
Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.
Key Applications
Immunohistochemistry
Flow Cytometry
Application Notes
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)
Biological Information
Immunogen
Mouse OX40L cDNA-transfected NRK cells
Epitope
Extracellular domain
Clone
RM134L
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rat
Specificity
This antibody recognizes the extracellular domain of OX40L.
FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
SUBUNIT STRUCTURE: Homotrimer.
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
SEQUENCE SIMILARITIES: Belongs to the tumor necrosis factor family.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in mouse OX40L/L5178Y cells.
Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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