Myotonic dystrophy (DM1) is a neuromuscular disorder associated with repeated CTG triplets in the 3'-untranslated region of the DMPK gene. It is hypothesized that the CUG repeats in the mRNA form hairpins that sequester nuclear factors required for proper muscle development and maintenance. MBNL (muscleblind-like protein 1) is an RNA splicing factor that binds to the CUG repeats and is enriched at these mutant RNA foci. MBNL-deficient mice are often used as a model for myotonic muscular dystrophy and siRNA downregulation of MBNL in normal myoblasts results in abnormal insulin receptor splicing.
Product Information
Format
Ascites
Control
Jurkat cell lysate
Presentation
Mouse ascites IgG1 in buffer containing 0.05% sodium azide.
Applications
Application
Anti-MBNL Antibody, clone 3A4 is a Mouse Monoclonal Antibody for detection of MBNL also known as Muscleblind-like protein 1, Triplet-expansion RNA-binding protein & has been validated in WB.
Key Applications
Western Blotting
Application Notes
Western Blot Analysis: A 1:1000 dilution of this lot detected MBNL-1 on Jurkat cell lysate. Optimal working dilutions must be determined by the end user.
Routinely evaluated by western blot on Jurkat cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size
100 µL
原厂资料：
Description
Catalogue Number
04-048
Brand Family
Upstate
Trade Name
Upstate
Description
Anti-MBNL Antibody, clone 3A4
Background Information
Myotonic dystrophy (DM1) is a neuromuscular disorder associated with repeated CTG triplets in the 3'-untranslated region of the DMPK gene. It is hypothesized that the CUG repeats in the mRNA form hairpins that sequester nuclear factors required for proper muscle development and maintenance. MBNL (muscleblind-like protein 1) is an RNA splicing factor that binds to the CUG repeats and is enriched at these mutant RNA foci. MBNL-deficient mice are often used as a model for myotonic muscular dystrophy and siRNA downregulation of MBNL in normal myoblasts results in abnormal insulin receptor splicing.
Product Information
Format
Ascites
Control
Jurkat cell lysate
Presentation
Mouse ascites IgG1 in buffer containing 0.05% sodium azide.
Applications
Application
Anti-MBNL Antibody, clone 3A4 is a Mouse Monoclonal Antibody for detection of MBNL also known as Muscleblind-like protein 1, Triplet-expansion RNA-binding protein & has been validated in WB.
Key Applications
Western Blotting
Application Notes
Western Blot Analysis: A 1:1000 dilution of this lot detected MBNL-1 on Jurkat cell lysate. Optimal working dilutions must be determined by the end user.
Routinely evaluated by western blot on Jurkat cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
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