100 µL concentration of 1mg/mL purified ascites in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Applications
Application
Anti-20S proteasome subunit α2 Antibody, clone MCP21 detects level of 20S proteasome subunit α2 & has been published & validated for use in IP, WB, IH.
Key Applications
Immunohistochemistry
Immunoprecipitation
Western Blotting
Biological Information
Immunogen
Human placenta derived proteasomes
Clone
MCP21
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
FUNCTION:SwissProt: P25787 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. SIZE:234 amino acids; 25899 Da SUBUNIT:The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure. SUBCELLULAR LOCATION:Cytoplasm. Nucleus. PTM:Phosphorylated on tyrosine residues; which may be important for nuclear import (By similarity). SIMILARITY:SwissProt: P25787 ## Belongs to the peptidase T1A family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of shipment for up to 12 months.
100 µL concentration of 1mg/mL purified ascites in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Applications
Application
Anti-20S proteasome subunit α2 Antibody, clone MCP21 detects level of 20S proteasome subunit α2 & has been published & validated for use in IP, WB, IH.
Key Applications
Immunohistochemistry
Immunoprecipitation
Western Blotting
Biological Information
Immunogen
Human placenta derived proteasomes
Clone
MCP21
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
FUNCTION:SwissProt: P25787 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. SIZE:234 amino acids; 25899 Da SUBUNIT:The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure. SUBCELLULAR LOCATION:Cytoplasm. Nucleus. PTM:Phosphorylated on tyrosine residues; which may be important for nuclear import (By similarity). SIMILARITY:SwissProt: P25787 ## Belongs to the peptidase T1A family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of shipment for up to 12 months.
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