A cell-permeable calpain inhibitor (ID50= 52 nM for calpain-1; ID50= 34 nM for calpain-2; ID50= 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
Catalogue Number
03-34-0051
Brand Family
Calbiochem®
Synonyms
Benzyloxycarbonylleucyl-norleucinal
References
References
Lee, M.S., et al. 2000.Nature405,360.
Yamazaki, T., et al. 1997.Biochemistry27,8377.
Klafki, H., et al. 1996.J. Biol. Chem.271,28655.
Shiba, E., et al. 1996.Anticancer Res.16,773.
Pinter, M., et al. 1994.Neurosci. Lett.170,91.
Saito, K., and Nixon, R.A. 1993.Neurochem. Res.18,231.
Tsujinaka, T., et al. 1988.Biochem. Biophys. Res. Commun.153,1201.
Product Information
CAS number
117591-20-5
ATP Competitive
N
Form
White to off-white solid
Hill Formula
C₂₀H₃₀N₂O₄
Chemical formula
C₂₀H₃₀N₂O₄
Molar Mass
362.5
Peptide Sequence
Z-Leu-Nle-CHO
Reversible
N
Structure formula Image
Biological Information
Primary Target
Calpain-1
Primary Target IC50
ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
Purity
≥94% by HPLC
Physicochemical Information
Cell permeable
Y
Solubility
DMSO or DMF
Peptide Sequence
Z-Leu-Nle-CHO
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
-20°C
Do not freeze
No
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
原厂资料：
Description
Overview
A cell-permeable calpain inhibitor (ID50= 52 nM for calpain-1; ID50= 34 nM for calpain-2; ID50= 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
Catalogue Number
03-34-0051
Brand Family
Calbiochem®
Synonyms
Benzyloxycarbonylleucyl-norleucinal
References
References
Lee, M.S., et al. 2000.Nature405,360.
Yamazaki, T., et al. 1997.Biochemistry27,8377.
Klafki, H., et al. 1996.J. Biol. Chem.271,28655.
Shiba, E., et al. 1996.Anticancer Res.16,773.
Pinter, M., et al. 1994.Neurosci. Lett.170,91.
Saito, K., and Nixon, R.A. 1993.Neurochem. Res.18,231.
Tsujinaka, T., et al. 1988.Biochem. Biophys. Res. Commun.153,1201.
Product Information
CAS number
117591-20-5
ATP Competitive
N
Form
White to off-white solid
Hill Formula
C₂₀H₃₀N₂O₄
Chemical formula
C₂₀H₃₀N₂O₄
Molar Mass
362.5
Peptide Sequence
Z-Leu-Nle-CHO
Reversible
N
Structure formula Image
Biological Information
Primary Target
Calpain-1
Primary Target IC50
ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
Purity
≥94% by HPLC
Physicochemical Information
Cell permeable
Y
Solubility
DMSO or DMF
Peptide Sequence
Z-Leu-Nle-CHO
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
-20°C
Do not freeze
No
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
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