Klotho is a type-I membrane protein which is related to beta-glucosidases. Reduced production of the Klotho protein is detected in patients with chronic renal failure (CRF), which may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. In addition, mutations within the Klotho protein are linked with ageing and bone loss.
The Klotho Human Recombinant is produced in CHO cells and fused with a C-terminal 6xHis Tag.
The Klotho His Tagged Fusion Protein is 59.5kDa protein containing a total of 522 amino acid residues and purified by proprietary chromatographic techniques.
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