MEK Inhibitor U0126

• 产品编号：V1121      品牌：promega       原厂货号：V1121
• 产品分类：生化试剂 > 生物试剂 > 生物活性小分子 > 抑制剂
• 应用分类：

其它组分：

描述：

原厂资料：

MEK Inhibitor U0126 is a chemically synthesized organic compound that inhibits activation of MAPK (ERK 1/2) by inhibiting the kinase activity of MAP Kinase Kinase (MAPKK or MEK 1/2). U0126 inhibits MEK1 with an IC50 of 0.5μM (in vitro). It has been used in both in vivo and in vitro studies of MEK. The chemical identity of MEK Inhibitor U0126 has been confirmed by proton NMR spectroscopy.

Features - Benefits

Potent: U0126 inhibits Raf-activated MEK1/2 in vitro with an IC50 of approximately 10–20μM.

Applications

For more information, see the Protocols & Applications Guide.

References

DeSilva, D.R. et al. (1998) J. Immunol. 160, 4175–81.
Favata, M. et al. (1998) J. Biol. Chem. 273, 18623–32.
Goueli, S. et al. (1998) Promega Notes 69, 6–8.
Tolwinski, N.S. et al. (1999) J. Biol. Chem. 274, 6168–74.
Li, C. et al. (1999) J. Biol. Chem. 274, 6747–53.
Duncia, J.V. et al. (1998) Bioorg. Med. Chem. Lett. 8, 2839–44.