Recombinant Human NEDD8 Vinyl Sulfone Protein, CF (50 UG)

产品编号：RD-UL-802-050 品牌：R&D 原厂货号：UL-802-050
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描述：

Molecule Information: NEDD8

Long Name: Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8

Aliases: Neddylin; Rub1

Entrez Gene IDs: 4738 (Human); 18002 (Mouse); 25490 (Rat)

Background: NEDD8 (Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8)
View NEDD8 IHC images. NEDD8 (Neural precursor cell-expressed developmentally down-regulated gene 8; also known as Rub1) is a 6-8 kDa member of the ubiquitin family of proteins. It is expressed in striated muscle, and via its C-terminal Gly, forms covalent bonds with cullin family proteins. This conjugation generates ubiquitin ligase activity that regulates cell cycle proteins. Human pro-NEDD8 is 81 amino acids (aa) in length. It contains one ubiquitin-like domain (aa 1-65), and a 4-5 aa C-terminal propeptide that is cleaved to expose a C-terminal Gly residue that is used to generate a Gly-Lys intermolecular bond. Mature human NEDD8 shows 100% aa identity to NEDD8 from both mouse and canine.