Recombinant Human His6-GABARAP Biotin Protein, CF (50 UG)

产品编号：RD-UL-412-050 品牌：R&D 原厂货号：UL-412-050
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描述：

Molecule Information: GABARAP
Long Name: gamma-Aminobutyric Acid Type A Receptor Associated Protein
Aliases: Apg8p1; ATG8A; FLC3B; MM46
Entrez Gene IDs: 11337 (Human); 56486 (Mouse); 58974 (Rat)
Background: GABARAP/Apg8p1
gamma-Aminobutyric Acid Receptor-associated Protein (GABARAP), also known as Apg8p1, is 117 amino acid (aa) protein with a predicted molecular weight of 14 kDa. It is a member of the GABARAP subfamily of the Autophagy-related 8 (Atg8) family of proteins. The GABARAP subfamily also includes GABARAPL1. GABARAP/Apg8p1 has 100% aa sequence identity with its mouse and rat orthologs and is orthologous to yeast Atg8. Atg8 family members show structural similarity with Ubiquitin, but lack aa sequence similarity. GABARAP/Apg8p1 was first described for its putative involvement GABA A Receptor trafficking. However, it is best known for its role in autophagy. GABARAP/Apg8p1 covalently attaches to phosphatidylethanolamine (PE) in the phagophore (autophagosome precursor) membrane using a Ubiquitin-like conjugation system that includes Ubiquitin-activating (E1)-, Ubiquitin-conjugating (E2)-, and Ubiquitin Ligase (E3)-like enzymes. Here it is involved in the later stages of autophagosome maturation. It may also be involved in cargo recruitment to autophagosomes.

原厂资料：

Molecule Information: GABARAP
Long Name: gamma-Aminobutyric Acid Type A Receptor Associated Protein
Aliases: Apg8p1; ATG8A; FLC3B; MM46
Entrez Gene IDs: 11337 (Human); 56486 (Mouse); 58974 (Rat)
Background: GABARAP/Apg8p1
gamma-Aminobutyric Acid Receptor-associated Protein (GABARAP), also known as Apg8p1, is 117 amino acid (aa) protein with a predicted molecular weight of 14 kDa. It is a member of the GABARAP subfamily of the Autophagy-related 8 (Atg8) family of proteins. The GABARAP subfamily also includes GABARAPL1. GABARAP/Apg8p1 has 100% aa sequence identity with its mouse and rat orthologs and is orthologous to yeast Atg8. Atg8 family members show structural similarity with Ubiquitin, but lack aa sequence similarity. GABARAP/Apg8p1 was first described for its putative involvement GABA A Receptor trafficking. However, it is best known for its role in autophagy. GABARAP/Apg8p1 covalently attaches to phosphatidylethanolamine (PE) in the phagophore (autophagosome precursor) membrane using a Ubiquitin-like conjugation system that includes Ubiquitin-activating (E1)-, Ubiquitin-conjugating (E2)-, and Ubiquitin Ligase (E3)-like enzymes. Here it is involved in the later stages of autophagosome maturation. It may also be involved in cargo recruitment to autophagosomes.