Canine IL-17 ELISpot Development Module, 5 Plate (1 KT)

• 产品编号：RD-SEL5848      品牌：R&D       原厂货号：SEL5848
• 产品分类：ELISA及其它免疫分析 > ELISpot及FluoroSpot > ELISpot试剂盒
• 应用分类：

描述：

Molecule Information:  IL-17/IL-17A

Long Name:  Interleukin 17

Aliases: CTLA-8; IL17A

Entrez Gene IDs: 3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine)

Background: IL-17 Ligands 
The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

原厂资料：

Molecule Information:  IL-17/IL-17A

Long Name:  Interleukin 17

Aliases: CTLA-8; IL17A

Entrez Gene IDs: 3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine)

Background: IL-17 Ligands 
The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

注意事项：

* Sold separately (see Other Reagents Required, below)
** Following an overnight incubation with capture antibody, 2 hour blocking step, and cell stimulation.
*** When using the protocol provided.