Phospho-GAP-43 (S41) Affinity Purified Polyclonal Ab (100 UL)

产品编号：RD-PPS006 品牌：R&D 原厂货号：PPS006
产品分类：抗体 > 一抗 > 磷酸化抗体
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描述：

Molecule Information: GAP-43

Long Name: Growth Associated Protein 43

Aliases: B-50; Basp2; Neuromodulin

Entrez Gene IDs: 2596 (Human); 14432 (Mouse); 29423 (Rat)

Background: GAP-43
GAP-43 is a neuron growth cone-associated member of the neuromodulin family. GAP-43 contains an N-terminal lipid binding motif, a calmodulin-binding IQ domain and a C-terminus with four potential serine phosphorylation sites, one of which inhibits the calmodulin binding. Unphosphorylated calmodulin-bound GAP-43 is always associated with neurite retraction, while phosphorylated GAP-43 stabilizes actin filaments and promotes growth cone extension.

原厂资料：

Molecule Information: GAP-43

Long Name: Growth Associated Protein 43

Aliases: B-50; Basp2; Neuromodulin

Entrez Gene IDs: 2596 (Human); 14432 (Mouse); 29423 (Rat)

Background: GAP-43
GAP-43 is a neuron growth cone-associated member of the neuromodulin family. GAP-43 contains an N-terminal lipid binding motif, a calmodulin-binding IQ domain and a C-terminus with four potential serine phosphorylation sites, one of which inhibits the calmodulin binding. Unphosphorylated calmodulin-bound GAP-43 is always associated with neurite retraction, while phosphorylated GAP-43 stabilizes actin filaments and promotes growth cone extension.