Background: TR alpha Thyroid hormone Receptor alpha (TR alpha, THRA; NR1A1) is a member of the nuclear hormone receptor superfamily. The ligands for TR alpha are the thyroid hormones, which exist in two forms: T4 (3,5,3',5'-tetraiodo-L-thyronine) and T3 (3,5,3'-tri-iodo-L-thyronine). TR alpha plays a critical role in the differentiation, growth, metabolism and physiology of a wide variety of tissues. The major partners of TRs are the RXRs, which strongly enhance their ability to bind to specific DNA sequences and contribute to the specificity of TR.
原厂资料:
Molecule Information: TR alpha/NR1A1
Long Name: Thyroid Hormone Receptor alpha
Aliases: NR1A1; THRA; v-ErbA1
Entrez Gene IDs: 7067 (Human)
Background: TR alpha Thyroid hormone Receptor alpha (TR alpha, THRA; NR1A1) is a member of the nuclear hormone receptor superfamily. The ligands for TR alpha are the thyroid hormones, which exist in two forms: T4 (3,5,3',5'-tetraiodo-L-thyronine) and T3 (3,5,3'-tri-iodo-L-thyronine). TR alpha plays a critical role in the differentiation, growth, metabolism and physiology of a wide variety of tissues. The major partners of TRs are the RXRs, which strongly enhance their ability to bind to specific DNA sequences and contribute to the specificity of TR.