描述：
Activin proteins are involved in a wide range of biological processes including mesoderm
induction, neural cell differentiation, bone remodeling, hematopoiesis, the regulation of
reproductive physiology, inflammation, and carcinogenesis.They function through heteromeric
complexes of type I and type II serine/threonine kinase receptors. Dimeric ligands bind to a
type II receptor, such as Activin Receptor IIA (ActRIIA), which then associates with a type I
receptor to initiate signal transduction. ActRIIA mediates the pleiotropic effects of Activins
and Inhibins as well as several members of the BMP and GDF families of TGFβ like proteins.
Mature human ActRIIA is a 70 kDa glycoprotein that consists of a 116 amino acid (aa)
extracellular domain (ECD), a 26 aa transmembrane segment, and a 352 aacytoplasmic region
that includes the kinase domain and a PDZbinding motif (5). Within the ECD, human ActRIIA
shares 98% aa sequence identity with mouse and rat ActRIIA. Signaling through ActRIIA is
modulated by its interaction with RGMB/DRAGON, Cripto, Endoglin/CD105, TGF-β
RIII/Betaglycan, or BAMBI.These interactions can enhance ligand-induced signaling or interfere
with signaling by preventing ActRIIA association with type I receptors. Activin-induced
responses can also be limited by the enhanced internalization of ActRIIA following its
association with the cytoplasmic protein ARIP2.
原厂资料：
Activin proteins are involved in a wide range of biological processes including mesoderm
induction, neural cell differentiation, bone remodeling, hematopoiesis, the regulation of
reproductive physiology, inflammation, and carcinogenesis.They function through heteromeric
complexes of type I and type II serine/threonine kinase receptors. Dimeric ligands bind to a
type II receptor, such as Activin Receptor IIA (ActRIIA), which then associates with a type I
receptor to initiate signal transduction. ActRIIA mediates the pleiotropic effects of Activins
and Inhibins as well as several members of the BMP and GDF families of TGFβ like proteins.
Mature human ActRIIA is a 70 kDa glycoprotein that consists of a 116 amino acid (aa)
extracellular domain (ECD), a 26 aa transmembrane segment, and a 352 aacytoplasmic region
that includes the kinase domain and a PDZbinding motif (5). Within the ECD, human ActRIIA
shares 98% aa sequence identity with mouse and rat ActRIIA. Signaling through ActRIIA is
modulated by its interaction with RGMB/DRAGON, Cripto, Endoglin/CD105, TGF-β
RIII/Betaglycan, or BAMBI.These interactions can enhance ligand-induced signaling or interfere
with signaling by preventing ActRIIA association with type I receptors. Activin-induced
responses can also be limited by the enhanced internalization of ActRIIA following its
association with the cytoplasmic protein ARIP2.
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