描述：
Activin isoforms and other members of the TGF-β superfamily exert their biological effects
by binding to heteromeric complexes of a type I and a type II serinethreonine kinase
receptor, both of which are essential for signal transduction. Seven type I and five type II
receptors, including the two type I and the two type II activin receptors, designated ActR-I(A),
ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. Through alternative mRNA
splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the
activin receptor system. Different activin isoforms bind with different highaffinities to the
various type II isoforms. Type I activin receptors do not bind directly to activin, but will
associate with the type II receptoractivin complex and initiate signal transduction. Besides
the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities.
ActR-I can also bind and form signaling complexes with the BMP-2/-7bound BMPRII. Activin
type II receptors are highly conserved. Human, mouse and rat type II activin receptors share
greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors
bind activin with high affinity, and are potent activin antagonists.
原厂资料：
Activin isoforms and other members of the TGF-β superfamily exert their biological effects
by binding to heteromeric complexes of a type I and a type II serinethreonine kinase
receptor, both of which are essential for signal transduction. Seven type I and five type II
receptors, including the two type I and the two type II activin receptors, designated ActR-I(A),
ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. Through alternative mRNA
splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the
activin receptor system. Different activin isoforms bind with different highaffinities to the
various type II isoforms. Type I activin receptors do not bind directly to activin, but will
associate with the type II receptoractivin complex and initiate signal transduction. Besides
the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities.
ActR-I can also bind and form signaling complexes with the BMP-2/-7bound BMPRII. Activin
type II receptors are highly conserved. Human, mouse and rat type II activin receptors share
greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors
bind activin with high affinity, and are potent activin antagonists.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
