描述：
CCL22, also named stimulated T cell chemotactic protein (STCP-1), is a CC chemokine initially
isolated from clones of monocytederived macrophages. Human CCL22 cDNA encodes a
precursor protein of 93 amino acid residues with a 24 amino acid residue predicted signal
peptide that is cleaved to yield a 69 amino acid residue mature 8 kDa protein. At the amino
acid sequence level, CCL22 shows less than 35% identity to other CC chemokine family
members. Human CCL22 is expressed in dendritic cells, macrophages and activated monocytes.
In addition, CCL22 expression is also detected in the tissues of thymus, lymph node and
appendix. The gene for human CCL22 has been mapped to chromosome 16 rather than
chromosome 17 where the genes for many human CC chemokines are clustered. Recombinant
or chemically synthesized mature CCL22 has been shown to induce chemotaxis or Ca2+
mobilization in dendritic cells, IL2 activated NK cells, and activated T lymphocytes. A CD8+ T
lymphocytederived secreted soluble activity that suppresses infection by primary non
syncytiuminducing and syncytiuminducing HIV1 isolates and the T-cell line-adapted isolate
HIV1IIIB, has been identified as CCL22. Based on aminoterminal sequence analysis, the major
CD8+T lymphocyte-derived CCL22 protein yielded an aminoterminal sequence of YGANM,
which is two amino acid residues shorter than the predicted mature CCL22. The difference in
potency between the two mature CCL22 isoforms has not been determined.
原厂资料：
CCL22, also named stimulated T cell chemotactic protein (STCP-1), is a CC chemokine initially
isolated from clones of monocytederived macrophages. Human CCL22 cDNA encodes a
precursor protein of 93 amino acid residues with a 24 amino acid residue predicted signal
peptide that is cleaved to yield a 69 amino acid residue mature 8 kDa protein. At the amino
acid sequence level, CCL22 shows less than 35% identity to other CC chemokine family
members. Human CCL22 is expressed in dendritic cells, macrophages and activated monocytes.
In addition, CCL22 expression is also detected in the tissues of thymus, lymph node and
appendix. The gene for human CCL22 has been mapped to chromosome 16 rather than
chromosome 17 where the genes for many human CC chemokines are clustered. Recombinant
or chemically synthesized mature CCL22 has been shown to induce chemotaxis or Ca2+
mobilization in dendritic cells, IL2 activated NK cells, and activated T lymphocytes. A CD8+ T
lymphocytederived secreted soluble activity that suppresses infection by primary non
syncytiuminducing and syncytiuminducing HIV1 isolates and the T-cell line-adapted isolate
HIV1IIIB, has been identified as CCL22. Based on aminoterminal sequence analysis, the major
CD8+T lymphocyte-derived CCL22 protein yielded an aminoterminal sequence of YGANM,
which is two amino acid residues shorter than the predicted mature CCL22. The difference in
potency between the two mature CCL22 isoforms has not been determined.
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