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描述:
GCP-2 (granulocyte chemotactic protein-2) also known as CXCL6, is a CXC chemokine initially
isolated as a neutrophil chemoattractant from the MG63 osteosarcoma cell line. Among
human CXC chemokines, GCP-2 is most closely related to ENA-78 (78% amino acid (aa)
sequence identity in the mature peptide region and 86% identity in the signal sequence).
The structure and sequence of the genes for human GCP-2 and ENA-78 also exhibit close
similarity suggesting the two genes may have originated from a gene duplication. LIX
(LPS-induced CXC chemokine) was initially cloned as a gene induced by LPS in mouse
fibroblasts. The predicted LIX protein sequence is identical to a previously purified mouse
protein designated mouse GCP-2 based on its amino sequence similarity (60% sequence
identity) to human GCP-2. Mouse GCP-2/LIX is also 54% identical with human ENA-78 at the
amino acid sequence level.
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