描述：
Roof plate-specific Spondin -2 isoform 1 (R-Spondin 2, RSPO2), also known as cysteine-rich
and single thrombospondin domain containing protein 2 (Cristin 2), is a 33 kDa secreted
protein that belongs to the R-Spondin family. The four R-Spondins regulate Wnt/β-catenin
signaling and overlap in expression and function. Like other R-Spondins, RSPO2 contains two
adjacent cysteine-rich furinlike domains (aa 90 -134) followed by a thrombospondin (TSP-1)
motif (aa 144 -204) and a Cterminal region rich in basic residues (aa 207 -243). The basic
region binds heparin and mediates cell surface retention and extracellular matrix attachment
while the furin-like domains are required for Wnt/βcatenin signaling. RSPO2 contains one
potential N-glycosylation site. Mature human RSPO2 shares 97-98% aa identity with mouse,
rat, equine, canine and bovine RSPO2 and ~40% aa identity with RSPO1, RSPO3 and RSPO4.
Of the three reported splice isoforms of human R-Spondin 2, isoform 2 lacks residues 1 -67 of
isoform 1, while isoform 3 has a glycine substitution for residues 32 - 95 of isoform 1.
Human RSPO2 is expressed in organs of endodermal origin in adults, including intestine and
lung, and is down-regulated in tumors of these tissues. In the embryonic mouse, RSPO2
expression is concentrated in the apical epidermal ridge, hippocampus, and developing muscle,
teeth and bones. Deletion of RSPO2 results in down-regulation of Wnt activity in these areas,
malformations of the facial skeleton and limbs, and respiratory failure at birth. RSPO2 is an
extracellular potentiator of Wnt/βcatenin signaling. It functions at least in part by binding
LRP-6, stimulating its longterm phosphorylation and down-regulating its internalization.
RSPO proteins, especially RSPO2 and RSPO3, also antagonize DKK1 activity by interfering with
DKK1-mediated LRP-6 and Kremen association.
原厂资料：
Roof plate-specific Spondin -2 isoform 1 (R-Spondin 2, RSPO2), also known as cysteine-rich
and single thrombospondin domain containing protein 2 (Cristin 2), is a 33 kDa secreted
protein that belongs to the R-Spondin family. The four R-Spondins regulate Wnt/β-catenin
signaling and overlap in expression and function. Like other R-Spondins, RSPO2 contains two
adjacent cysteine-rich furinlike domains (aa 90 -134) followed by a thrombospondin (TSP-1)
motif (aa 144 -204) and a Cterminal region rich in basic residues (aa 207 -243). The basic
region binds heparin and mediates cell surface retention and extracellular matrix attachment
while the furin-like domains are required for Wnt/βcatenin signaling. RSPO2 contains one
potential N-glycosylation site. Mature human RSPO2 shares 97-98% aa identity with mouse,
rat, equine, canine and bovine RSPO2 and ~40% aa identity with RSPO1, RSPO3 and RSPO4.
Of the three reported splice isoforms of human R-Spondin 2, isoform 2 lacks residues 1 -67 of
isoform 1, while isoform 3 has a glycine substitution for residues 32 - 95 of isoform 1.
Human RSPO2 is expressed in organs of endodermal origin in adults, including intestine and
lung, and is down-regulated in tumors of these tissues. In the embryonic mouse, RSPO2
expression is concentrated in the apical epidermal ridge, hippocampus, and developing muscle,
teeth and bones. Deletion of RSPO2 results in down-regulation of Wnt activity in these areas,
malformations of the facial skeleton and limbs, and respiratory failure at birth. RSPO2 is an
extracellular potentiator of Wnt/βcatenin signaling. It functions at least in part by binding
LRP-6, stimulating its longterm phosphorylation and down-regulating its internalization.
RSPO proteins, especially RSPO2 and RSPO3, also antagonize DKK1 activity by interfering with
DKK1-mediated LRP-6 and Kremen association.
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