描述：
CCL6, also known as C10 and SCYA6, is an 11 kDa member of the MIP-I family of β-chemokines.
CCL6, along with CCL9, CCL15, and CCL23, belongs to the N6 subfamily of proteins that have an
N-terminal extension relative to other β-chemokines.The mouse CCL6 cDNA encodes a 116
amino acid (aa) precursor that includes a 21 aa signal sequence. Removal of an additional 20 aa
at the Nterminal results in an 8 kDa protein (aa 42 116) and the transition from a weak CCR1
agonist to a dramatically more potent and efficacious macrophage chemoattractant.The
Nterminal region of CCL6 and other N6 subfamily chemokines is cleaved following incubation
with synovial fluid from inflamed joints as well as with inflammationassociated proteases
such as chymase, cathepsin G, and elastase.CCL6 is upregulated in activated macrophages at
sites of inflammation and functions as a chemoattractant for additional macrophage influx.
The inflammatory cytokine IL-13 stimulates CCL6 production which then induces the release
of CCL2, CCL3, and proteases involved in tissue repair. CCL6 expression is upregulated by the
oncoprotein LMyc but repressed by cMyc. CCL6 induced by L-Myc promotes cellular
transformation and the development of a tumorigenic phenotype. N-terminally truncated
mouse CCL6 shares 77% and 64% aa sequence identity with rat CCL6 and mouse CCL9,
respectively. A human orthologue for mouse CCL6 has not been identified. Conversely, CCL15
and CCL23 and other members of the N6 subfamily have been described in human but not
in mouse.
原厂资料：
CCL6, also known as C10 and SCYA6, is an 11 kDa member of the MIP-I family of β-chemokines.
CCL6, along with CCL9, CCL15, and CCL23, belongs to the N6 subfamily of proteins that have an
N-terminal extension relative to other β-chemokines.The mouse CCL6 cDNA encodes a 116
amino acid (aa) precursor that includes a 21 aa signal sequence. Removal of an additional 20 aa
at the Nterminal results in an 8 kDa protein (aa 42 116) and the transition from a weak CCR1
agonist to a dramatically more potent and efficacious macrophage chemoattractant.The
Nterminal region of CCL6 and other N6 subfamily chemokines is cleaved following incubation
with synovial fluid from inflamed joints as well as with inflammationassociated proteases
such as chymase, cathepsin G, and elastase.CCL6 is upregulated in activated macrophages at
sites of inflammation and functions as a chemoattractant for additional macrophage influx.
The inflammatory cytokine IL-13 stimulates CCL6 production which then induces the release
of CCL2, CCL3, and proteases involved in tissue repair. CCL6 expression is upregulated by the
oncoprotein LMyc but repressed by cMyc. CCL6 induced by L-Myc promotes cellular
transformation and the development of a tumorigenic phenotype. N-terminally truncated
mouse CCL6 shares 77% and 64% aa sequence identity with rat CCL6 and mouse CCL9,
respectively. A human orthologue for mouse CCL6 has not been identified. Conversely, CCL15
and CCL23 and other members of the N6 subfamily have been described in human but not
in mouse.
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