描述：
BMP-4 is a TGF-β superfamily ligand that is widely expressed from early embryogenesis
through adulthood. It plays an important role in mesenchyme formation, epidermal
determination, suppression of neural induction, the development of multiple organs, and
tissue repair. The human BMP-4 precursor contains a 273 amino acid (aa) propeptide and a
116 aa mature protein.Processing of the propeptide by furin or proprotein convertase 6 enables
the formation of the mature disulfidelinked homodimeric BMP-4 and facilitates its secretion.
Similar intracellular processes may lead to the formation and recreation of BMP4/BMP7
disulfidelinked heterodimer. Mature human and mouse BMP-4 share 98% aa sequence
identity. Human BMP-4 shares 85% aa sequence identity with human BMP2 and less than
50% with other human BMPs. Compared to BMP-4 homodimers, BMP-4/BMP7 heterodimers
exhibit a greater potency in inducing osteogenic differentiation. In Xenopus, the heterodimers
can also induce the formation of mesoderm, whereas BMP-4 homodimers only provide
ventralizing signals for existing mesoderm. BMP-4 signals through tetrameric complexes
composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or
BMPRII) receptors. The bioavailability of BMP-4 is regulated by its interaction with multiple
proteins and glycosaminoglycans.
原厂资料：
BMP-4 is a TGF-β superfamily ligand that is widely expressed from early embryogenesis
through adulthood. It plays an important role in mesenchyme formation, epidermal
determination, suppression of neural induction, the development of multiple organs, and
tissue repair. The human BMP-4 precursor contains a 273 amino acid (aa) propeptide and a
116 aa mature protein.Processing of the propeptide by furin or proprotein convertase 6 enables
the formation of the mature disulfidelinked homodimeric BMP-4 and facilitates its secretion.
Similar intracellular processes may lead to the formation and recreation of BMP4/BMP7
disulfidelinked heterodimer. Mature human and mouse BMP-4 share 98% aa sequence
identity. Human BMP-4 shares 85% aa sequence identity with human BMP2 and less than
50% with other human BMPs. Compared to BMP-4 homodimers, BMP-4/BMP7 heterodimers
exhibit a greater potency in inducing osteogenic differentiation. In Xenopus, the heterodimers
can also induce the formation of mesoderm, whereas BMP-4 homodimers only provide
ventralizing signals for existing mesoderm. BMP-4 signals through tetrameric complexes
composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or
BMPRII) receptors. The bioavailability of BMP-4 is regulated by its interaction with multiple
proteins and glycosaminoglycans.
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