描述：
Flt-3 Ligand, also known as FL, is an α-helical cytokine that promotes the differentiation of
multiple hematopoietic cell lineages. Mature human Flt-3 Ligand consists of a 158 amino acid
(aa) extracellular domain (ECD) with a cytokinelike domain and a juxtamembrane tether
region, a 21 aa transmembrane segment, and a 30 aa cytoplasmic tail. Within the ECD, human
Flt-3 Ligand shares 71% and 65% aa sequence identity with mouse and rat Flt-3 Ligand,
respectively. Human and mouse Flt-3 Ligand show crossspecies activity. Flt-3 Ligand is
expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts.
Each 36 kDa chain carries approximately 12 kDa of N-and O-linked carbohydrates. Alternate
splicing and proteolytic cleavage of the transmembrane form can generate a soluble 30 kDa
fragment that includes the cytokine domain. Alternate splicing of human Flt-3 Ligand also
generates membraneassociated isoforms that contain either a truncated cytoplasmic tail or
an 85 aa substitution following the cytokine domain. Both transmembrane and soluble Flt-3
Ligand signal through the tyrosine kinase receptor Flt3/Flk2. Flt-3 Ligand induces the
expansion of monocytes and immature dendritic cells as well as early B cell lineage
differentiation. It synergizes with IL-3, GM-CSF, and SCF to promote the mobilization and
myeloid differentiation of hematopoietic stem cells. It cooperates with IL-2, -6, -7, and -15 to
induce NK cell development and with IL-3, -7, and -11 to induce terminal B cell maturation.
Animal studies also show Flt-3 Ligand to reduce the severity of experimentally induced
allergic inflammation.
原厂资料：
Flt-3 Ligand, also known as FL, is an α-helical cytokine that promotes the differentiation of
multiple hematopoietic cell lineages. Mature human Flt-3 Ligand consists of a 158 amino acid
(aa) extracellular domain (ECD) with a cytokinelike domain and a juxtamembrane tether
region, a 21 aa transmembrane segment, and a 30 aa cytoplasmic tail. Within the ECD, human
Flt-3 Ligand shares 71% and 65% aa sequence identity with mouse and rat Flt-3 Ligand,
respectively. Human and mouse Flt-3 Ligand show crossspecies activity. Flt-3 Ligand is
expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts.
Each 36 kDa chain carries approximately 12 kDa of N-and O-linked carbohydrates. Alternate
splicing and proteolytic cleavage of the transmembrane form can generate a soluble 30 kDa
fragment that includes the cytokine domain. Alternate splicing of human Flt-3 Ligand also
generates membraneassociated isoforms that contain either a truncated cytoplasmic tail or
an 85 aa substitution following the cytokine domain. Both transmembrane and soluble Flt-3
Ligand signal through the tyrosine kinase receptor Flt3/Flk2. Flt-3 Ligand induces the
expansion of monocytes and immature dendritic cells as well as early B cell lineage
differentiation. It synergizes with IL-3, GM-CSF, and SCF to promote the mobilization and
myeloid differentiation of hematopoietic stem cells. It cooperates with IL-2, -6, -7, and -15 to
induce NK cell development and with IL-3, -7, and -11 to induce terminal B cell maturation.
Animal studies also show Flt-3 Ligand to reduce the severity of experimentally induced
allergic inflammation.
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