描述：
Human Wnt-7a is one of about 19 vertebrate members of the Wingless-type MMTV
integration site (Wnt) family of highly conserved cysteinerich secreted glycoproteins
important for normal developmental processes. Wnts bind to receptors of the Frizzled
family in conjunction with low-density lipoprotein receptorrelated proteins (LRPs).
Downstream effects of Wnt signaling occur through activation of one of three different
intracellular pathways: the canonical Wnt pathway, Wnt/Ca 2+ pathway, and planar cell
polarity. The highly transforming Wnts, including Wnt-1, -3, -3a, -7a and -8 activate the
canonical pathway, which regulates β-cateninmediated gene expression. Human Wnt-7a
is a 48 kDa secreted glycoprotein containing 24 cysteine residues that is expressed by
epithelial and epitheliallyderived cells of the placenta, kidney, testis, uterus, fetal lung and
fetal and adult brain. Palmitate modification of a cysteine residue has been shown for Wnt3a;
this site is conserved on all Wnts and is Cys73 on Wnt-7a. When modified, increased
hydrophobicity and activity is expected. Human Wnt-7a shows 97% aa identity with mouse,
rat and dog Wnt7a and 92% aa identity with chicken Wnt7a. During development, Wnt-7a is
expressed by the dorsal ectoderm and drives expression of homeodomain transcription
factors that control effectors important in patterning and cell fates in adjacent mesenchyme.
When Wnt-7a is deleted, mice show disruption of dorsalization and anterior/posterior
patterning during limb development and abnormalities in the reproductive tract. Wnt-7a is
frequently downregulated in leukemia and lung cancers, potentially affecting homeobox (HOX)
gene expression, differentiation state and growth control. Roles for Wnt-7a have also been
shown during formation of neural synapses, response of the uterus to estrogen and
inflammatory cartilage destruction.
原厂资料：
Human Wnt-7a is one of about 19 vertebrate members of the Wingless-type MMTV
integration site (Wnt) family of highly conserved cysteinerich secreted glycoproteins
important for normal developmental processes. Wnts bind to receptors of the Frizzled
family in conjunction with low-density lipoprotein receptorrelated proteins (LRPs).
Downstream effects of Wnt signaling occur through activation of one of three different
intracellular pathways: the canonical Wnt pathway, Wnt/Ca 2+ pathway, and planar cell
polarity. The highly transforming Wnts, including Wnt-1, -3, -3a, -7a and -8 activate the
canonical pathway, which regulates β-cateninmediated gene expression. Human Wnt-7a
is a 48 kDa secreted glycoprotein containing 24 cysteine residues that is expressed by
epithelial and epitheliallyderived cells of the placenta, kidney, testis, uterus, fetal lung and
fetal and adult brain. Palmitate modification of a cysteine residue has been shown for Wnt3a;
this site is conserved on all Wnts and is Cys73 on Wnt-7a. When modified, increased
hydrophobicity and activity is expected. Human Wnt-7a shows 97% aa identity with mouse,
rat and dog Wnt7a and 92% aa identity with chicken Wnt7a. During development, Wnt-7a is
expressed by the dorsal ectoderm and drives expression of homeodomain transcription
factors that control effectors important in patterning and cell fates in adjacent mesenchyme.
When Wnt-7a is deleted, mice show disruption of dorsalization and anterior/posterior
patterning during limb development and abnormalities in the reproductive tract. Wnt-7a is
frequently downregulated in leukemia and lung cancers, potentially affecting homeobox (HOX)
gene expression, differentiation state and growth control. Roles for Wnt-7a have also been
shown during formation of neural synapses, response of the uterus to estrogen and
inflammatory cartilage destruction.
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