描述：
Wnt proteins are cysteine-rich secreted glycoproteins that play critical roles in both
carcinogenesis and embryonic development. Wnts bind to receptors of the Frizzled
family in conjunction with a coreceptor of the lowdensity lipoprotein receptorrelated
protein family (LRP-5 or -6), or the Ryk atypical receptor tyrosine kinase. Downstream
effects of Wnt signaling occur through multiple pathways with differing intracellular
components: the canonical Wnt/βcatenin pathway, the Wnt/Ca2+pathway, and the
planar cell polarity (PCP) pathway. Wnt-5b is a 49 kDa glycoprotein that is implicated
in the Wnt/Ca2+ and PCP pathways. These pathways can inhibit canonical Wnt/βcatenin
signaling. Human and mouse Wnt5b are synthesized as 359 amino acid (aa) precursors that
contain a 17 aa signal sequence and a 342 aa mature region. Mature mouse Wnt-5b shares
94%, 98%, 90% and 88% aa identity with mature human, rat, chick and Xenopus Wnt-5b,
respectively. Although Wnt-5a and Wnt-5b share 83% aa identity, their effects may be
different. For example, Wnt-5b, but not Wnt-5a, promotes cell cycle progression and is
weakly transforming. Wnt-5a and -5b are thought to coordinate developmental events,
such as chondrocyte differentiation and formation of endochondral bone. In contrast to more
focused expression of Wnt-5a, Wnt-5b is constitutively expressed at low levels throughout
mouse embryonic development. In adult mice, Wnt-5b is widely expressed, including heart,
liver, brain, lung, testes, kidney, and pancreas. Wnt-5b is up-regulated during early
adipogenesis, and its overexpression in 3T3-L1 cells partially inhibits canonical Wnt
suppression of adipogenesis. It enhances PPARγ expression and promotes differentiation of
preadipocytes. Human Wnt5b polymorphisms have been associated with Type II diabetes.
原厂资料：
Wnt proteins are cysteine-rich secreted glycoproteins that play critical roles in both
carcinogenesis and embryonic development. Wnts bind to receptors of the Frizzled
family in conjunction with a coreceptor of the lowdensity lipoprotein receptorrelated
protein family (LRP-5 or -6), or the Ryk atypical receptor tyrosine kinase. Downstream
effects of Wnt signaling occur through multiple pathways with differing intracellular
components: the canonical Wnt/βcatenin pathway, the Wnt/Ca2+pathway, and the
planar cell polarity (PCP) pathway. Wnt-5b is a 49 kDa glycoprotein that is implicated
in the Wnt/Ca2+ and PCP pathways. These pathways can inhibit canonical Wnt/βcatenin
signaling. Human and mouse Wnt5b are synthesized as 359 amino acid (aa) precursors that
contain a 17 aa signal sequence and a 342 aa mature region. Mature mouse Wnt-5b shares
94%, 98%, 90% and 88% aa identity with mature human, rat, chick and Xenopus Wnt-5b,
respectively. Although Wnt-5a and Wnt-5b share 83% aa identity, their effects may be
different. For example, Wnt-5b, but not Wnt-5a, promotes cell cycle progression and is
weakly transforming. Wnt-5a and -5b are thought to coordinate developmental events,
such as chondrocyte differentiation and formation of endochondral bone. In contrast to more
focused expression of Wnt-5a, Wnt-5b is constitutively expressed at low levels throughout
mouse embryonic development. In adult mice, Wnt-5b is widely expressed, including heart,
liver, brain, lung, testes, kidney, and pancreas. Wnt-5b is up-regulated during early
adipogenesis, and its overexpression in 3T3-L1 cells partially inhibits canonical Wnt
suppression of adipogenesis. It enhances PPARγ expression and promotes differentiation of
preadipocytes. Human Wnt5b polymorphisms have been associated with Type II diabetes.
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