描述：
Insulinlike growth factor I, also known as somatomedin C, is the dominant effector of growth
hormone and is structurally homologous to proinsulin. Human IGFI is synthesized as two
precursor isoforms with N-and alternate C-terminal propeptides. These isoforms are
differentially expressed by various tissues. The 7.6 kDa mature IGFI is identical between
isoforms and is generated by proteolytic removal of the N-and C-terminal regions. Mature
human IGFI shares 94% and 96% aa sequence identity with mouse and rat IGFI, respectively,
and exhibits crossspecies activity. It shares 64% aa sequence identity with mature human
IGFII. Circulating IGFI is produced by hepatocytes, while local IGFI is produced by many
other tissues in which it has paracrine effects. IGFI induces the proliferation, migration, and
differentiation of a wide variety of cell types during development and postnatally. IGFI
regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone
metabolism. It plays an important role in muscle regeneration and tumor progression.
IGFI binds IGFI R, IGFII R, and the insulin receptor, although its effects are mediated primarily
by IGFI R. IGFI association with IGF binding proteins increases its plasma halflife and
modulates its interactions with receptors.
原厂资料：
Insulinlike growth factor I, also known as somatomedin C, is the dominant effector of growth
hormone and is structurally homologous to proinsulin. Human IGFI is synthesized as two
precursor isoforms with N-and alternate C-terminal propeptides. These isoforms are
differentially expressed by various tissues. The 7.6 kDa mature IGFI is identical between
isoforms and is generated by proteolytic removal of the N-and C-terminal regions. Mature
human IGFI shares 94% and 96% aa sequence identity with mouse and rat IGFI, respectively,
and exhibits crossspecies activity. It shares 64% aa sequence identity with mature human
IGFII. Circulating IGFI is produced by hepatocytes, while local IGFI is produced by many
other tissues in which it has paracrine effects. IGFI induces the proliferation, migration, and
differentiation of a wide variety of cell types during development and postnatally. IGFI
regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone
metabolism. It plays an important role in muscle regeneration and tumor progression.
IGFI binds IGFI R, IGFII R, and the insulin receptor, although its effects are mediated primarily
by IGFI R. IGFI association with IGF binding proteins increases its plasma halflife and
modulates its interactions with receptors.
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