Recombinant Human CCL7/MCP-3 Protein, CF (10 UG)

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运保温度:

at ambient temperature

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描述：

MCP-2 and CCL7 are two monocyte chemotactic proteins produced by human MG-63

osteosarcoma cells. Both MCP-2 and CCL7 are members of the C-C family of chemokines

and share 62% and 71% amino acid sequence identity, respectively, with MCP-1. CCL7

also shares 58% amino acid identity with MCP-2.

CCL7 cDNA encodes a 99 amino acid residue precursor protein from which the N-terminal

23 amino acid residues are cleaved to generate the 76 amino acid residue mature CCL7.

Mature CCL7 contains a potential Nlinked and several possible O-linked glycosylation sites.

Similarly to other C-C chemokines, all three MCP proteins are monocyte chemoattractants. In

addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T

lymphocytes. All three cytokines have also been shown to attract eosinophils and induce

histamine secretion from basophils.

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