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描述:
MCP-2 and MCP-3 are two monocyte chemotactic proteins produced by human MG-63
osteosarcoma cells. Both MCP-2 and MCP-3 are members of the C-C family ofchemokines
and share 62% and 71% amino acid sequence identity, respectively, with MCP-1. MCP-3 also
shares 58% amino acid identity with MCP-2.Similarly to other C-C chemokines, all three MCP
proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract
activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also
been shown to attract eosinophils and induce histamine secretion from basophils.
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