描述：
CCL3, also known as macrophage inflammatory protein 1 alpha (MIP-1α) and LD78, is a
member of the β or CC subfamily of chemokines and is closely related to CCL4/MIP-1β.
Chemokines comprise a large family of small secreted proteins that are involved in immune
and inflammatory responses. CCL3 expression can be induced in a variety of hematopoietic
cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature human CCL3 shares 70% -
74% amino acid sequence identity with mouse, rat, and cotton rat CCL3. CCL3 is an
approximately 8 kDa chemokine that forms complexes with sulfated proteoglycans.
In a reversible process, CCL3 associates into noncovalently-linked dimers which then form
tetramers and high molecular weight polymers. These complexes of CCL3 are protected
from proteolytic digestion by insulin degrading enzyme (IDE) which can cleave the
monomeric chemokine. CCL3 exerts its biological functions through interactions with CCR1,
CCR3, and CCR5. It is cleared from the extracellular space by internalization via the decoy
chemokine receptor D6. CCL3 promotes the chemoattraction, adhesion to activated vascular
endothelium, and cellular activation of many hematopoietic cell types including activated T
cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils. CCL3 is also
known as stem cell inhibitor (SCI) and can inhibit the proliferation of hematopoietic progenitor
cells. CCL3 bioactivity contributes to tumor metastasis and the inflammatory components
of viral infection, rheumatoid arthritis, and hepatitis, although it also can suppress the
replication of HIV. CCL3 additionally promotes hyperalgesia by sensitizing sensory neurons to
TRPV1mediated noxious stimulation.
原厂资料：
CCL3, also known as macrophage inflammatory protein 1 alpha (MIP-1α) and LD78, is a
member of the β or CC subfamily of chemokines and is closely related to CCL4/MIP-1β.
Chemokines comprise a large family of small secreted proteins that are involved in immune
and inflammatory responses. CCL3 expression can be induced in a variety of hematopoietic
cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature human CCL3 shares 70% -
74% amino acid sequence identity with mouse, rat, and cotton rat CCL3. CCL3 is an
approximately 8 kDa chemokine that forms complexes with sulfated proteoglycans.
In a reversible process, CCL3 associates into noncovalently-linked dimers which then form
tetramers and high molecular weight polymers. These complexes of CCL3 are protected
from proteolytic digestion by insulin degrading enzyme (IDE) which can cleave the
monomeric chemokine. CCL3 exerts its biological functions through interactions with CCR1,
CCR3, and CCR5. It is cleared from the extracellular space by internalization via the decoy
chemokine receptor D6. CCL3 promotes the chemoattraction, adhesion to activated vascular
endothelium, and cellular activation of many hematopoietic cell types including activated T
cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils. CCL3 is also
known as stem cell inhibitor (SCI) and can inhibit the proliferation of hematopoietic progenitor
cells. CCL3 bioactivity contributes to tumor metastasis and the inflammatory components
of viral infection, rheumatoid arthritis, and hepatitis, although it also can suppress the
replication of HIV. CCL3 additionally promotes hyperalgesia by sensitizing sensory neurons to
TRPV1mediated noxious stimulation.
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