描述：
KGF (keratinocyte growth factor), also known as FGF-7 (fibroblast growth factor-7), is one of
22 known members of the mouse FGF family of secreted proteins that plays a key role in
development, morphogenesis, angiogenesis, wound healing, and tumorigenesis. KGF
expression is restricted to cells of mesenchymal origin. When secreted, it acts as a paracrine
growth factor for nearby epithelial cells. KGF speeds wound healing by being dramatically
upregulated in response to damage to skin or internal structures that results in high local
concentrations of inflammatory mediators such as IL1 and TNF-α. KGF promotes cell migration
and invasion, and mediates melanocyte transfer to keratinocytes upon UVB radiation. It has
been used ectopically to avoid chemotherapyinduced oral mucositis in patients with
hematological malignancies. Deletion of KGF affects kidney development, producing abnormally
small ureteric buds and fewer nephrons. It also impedes hair follicle differentiation. The 194
amino acid (aa) KGF precursor contains a 31 aa signal sequence and, like all other FGFs, an 120
aa βtrefoil scaffold that includes receptorand heparinbinding sites. KGF signals only through
the IIIb splice form of the tyrosine kinase receptor, FGF R2 (FGF R2-IIIb/KGF R). Receptor
dimerization requires an octameric or larger heparin or heparin sulfate proteoglycan. FGF-10,
also called KGF2, shares 51% aa identity and similar function to KGF, but shows more limited
expression than KGF and uses an additional receptor, FGF R2-IIIc. Following receptor
engagement, KGF is typically degraded, while FGF-10 is recycled. Mature human KGF, which is
active across species, shares 98% aa sequence identity with bovine, equine, ovine and canine,
96% with mouse and porcine, and 92% with rat KGF, respectively.
原厂资料：
KGF (keratinocyte growth factor), also known as FGF-7 (fibroblast growth factor-7), is one of
22 known members of the mouse FGF family of secreted proteins that plays a key role in
development, morphogenesis, angiogenesis, wound healing, and tumorigenesis. KGF
expression is restricted to cells of mesenchymal origin. When secreted, it acts as a paracrine
growth factor for nearby epithelial cells. KGF speeds wound healing by being dramatically
upregulated in response to damage to skin or internal structures that results in high local
concentrations of inflammatory mediators such as IL1 and TNF-α. KGF promotes cell migration
and invasion, and mediates melanocyte transfer to keratinocytes upon UVB radiation. It has
been used ectopically to avoid chemotherapyinduced oral mucositis in patients with
hematological malignancies. Deletion of KGF affects kidney development, producing abnormally
small ureteric buds and fewer nephrons. It also impedes hair follicle differentiation. The 194
amino acid (aa) KGF precursor contains a 31 aa signal sequence and, like all other FGFs, an 120
aa βtrefoil scaffold that includes receptorand heparinbinding sites. KGF signals only through
the IIIb splice form of the tyrosine kinase receptor, FGF R2 (FGF R2-IIIb/KGF R). Receptor
dimerization requires an octameric or larger heparin or heparin sulfate proteoglycan. FGF-10,
also called KGF2, shares 51% aa identity and similar function to KGF, but shows more limited
expression than KGF and uses an additional receptor, FGF R2-IIIc. Following receptor
engagement, KGF is typically degraded, while FGF-10 is recycled. Mature human KGF, which is
active across species, shares 98% aa sequence identity with bovine, equine, ovine and canine,
96% with mouse and porcine, and 92% with rat KGF, respectively.
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