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描述:
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic
factors (also named neurotrophins) that are required for the differentiation and survival
of specific neuronal subpopulations in both the central as well as the peripheral nervous
system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF,
NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are
proteolytically processed to generate the mature proteins. All neurotrophins have six
conserved cysteine residues that are involved in the formation of three disulfide bonds and
all share approximately 55% sequence identity at the amino acid level. Similarly to NGF,
bioactive BDNF is predicted to be a non-covalently linked homodimer.
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