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描述:
Flt-3 Ligand, also known as FL, is an α-helical cytokine that promotes the differentiation of
multiple hematopoietic cell lineages. Mature feline Flt-3 Ligand consists of a 156 amino acid
(aa) extracellular region with a cytokine-like domain and a juxtamembrane tether region, a 21
aa transmembrane segment, and an 88 aa cytoplasmic tail. Within the ECD, feline Flt-3 Ligand
shares 92%, 81%, 70%, and 63% aa sequence identity with canine, human, mouse, and rat Flt-3
Ligand, respectively. Flt-3 Ligand is expressed as a noncovalentlylinked dimer by T cells and
bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N-and
O-linked carbohydrates. Alternate splicing and proteolytic cleavage of the transmembrane form
can generate a soluble 30 kDa fragment that includes the cytokine domain. Multiple splice forms
of canine, human, and mouse Flt-3 Ligand have been described and may also exist in feline .
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