描述：
FGF-4 (fibroblast growth factor-4), also known as FGF-K or K-FGF (Kaposi’s sarcomaassociated
FGF), is a 25 kDa secreted, heparin-binding member of the FGF family. The human FGF-4 cDNA
encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with
an FGF homology domain that contains a heparin binding region near the C-terminus.Mature
human FGF-4 (aa 71-206) shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine
and bovine FGF-4, respectively. Human FGF-4 has been shown to exhibit cross species activity.
Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated
during embryonic development.Its expression in the mouse trophoblast inner cell mass promotes
expression of FGF R2, and is required for maintenance of the trophectoderm and primitive endoderm.
Later in mouse development, FGF-4 works together with FGF-8 to mediate the activities of
the apical ectodermal ridge, which direct the outgrowth and patterning of vertebrate limbs.
FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell
selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on
context and concentration, and is often included in embryonic stem cell media in vitro. A
C-terminally truncated 15 kDa isoform that opposes fulllength FGF-4 and promotes
differentiation is endogenously expressed in human embryonic stem cells. FGF-4 is mitogenic
for fibroblasts and endothelial cells in vitro and has autocrine transforming potential.It is a
potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery
disease.
原厂资料：
FGF-4 (fibroblast growth factor-4), also known as FGF-K or K-FGF (Kaposi’s sarcomaassociated
FGF), is a 25 kDa secreted, heparin-binding member of the FGF family. The human FGF-4 cDNA
encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with
an FGF homology domain that contains a heparin binding region near the C-terminus.Mature
human FGF-4 (aa 71-206) shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine
and bovine FGF-4, respectively. Human FGF-4 has been shown to exhibit cross species activity.
Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated
during embryonic development.Its expression in the mouse trophoblast inner cell mass promotes
expression of FGF R2, and is required for maintenance of the trophectoderm and primitive endoderm.
Later in mouse development, FGF-4 works together with FGF-8 to mediate the activities of
the apical ectodermal ridge, which direct the outgrowth and patterning of vertebrate limbs.
FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell
selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on
context and concentration, and is often included in embryonic stem cell media in vitro. A
C-terminally truncated 15 kDa isoform that opposes fulllength FGF-4 and promotes
differentiation is endogenously expressed in human embryonic stem cells. FGF-4 is mitogenic
for fibroblasts and endothelial cells in vitro and has autocrine transforming potential.It is a
potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery
disease.
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