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描述:
FGF acidic, also known as FGF-1, ECGF, and HBGF-1, is a 17 kDa nonglycosylated member of
the FGF family of mitogenic peptides. FGF acidic, which is produced by multiple cell types,
stimulates the proliferation of all cells of mesodermal origin and many cells of
neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in
development, regeneration, and angiogenesis. Human FGF acidic shares 54% amino acid
sequence identity with FGF basic and 17%- 33% with other human FGFs. It shares 92%, 96%,
96%, and 96% aa sequence identity with bovine, mouse, porcine, and rat FGF acidic,
respectively, and exhibits considerable species crossreactivity.
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